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In contrast, 4-hydroxylated estrogens might exert pro-inflammatory roles by inducing ROS and DNA damage

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Simultaneously, the formation of short-lived radical, monodehydroascorbate (MDA • ), happen, which may be spontaneously converted to Asc and dehydroascorbate (DHA), and/or might be rapidly reduced to Asc by NAD(P)H-dependent monodehydroascorbate reductase (MDAR, EC 1.6.5.4