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Best candidates for retatrutide Retatrutide makes more sense for researchers who: Need maximum possible weight loss and have not achieved adequate results with dual agonists Have significant liver fat accumulation as a primary concern Have plateaued on tirzepatide or stopped responding Are comfortable with investigational compounds and research-grade sourcing Have higher side effect tolerance Want the most comprehensive metabolic intervention currently available Are experienced with GLP-1 agonist protocols and understand escalation management Have access to medical monitoring during the protocol Retatrutide is not a beginner compound

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One report demonstrates that MORs inhibit GABAergic transmission in both NAc shell and core, however, MORs have a larger effect on GABA transmission in the shell (Ma et al., 2012)