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The Controversial Role of Glucose-6-Phosphate Dehydrogenase Deficiency on Cardiovascular Disease: A Narrative Review - PMC

Intrinsically, PanCa exhibits gain of function mutations of KRAS gene (approximately 90% of cases) and loss of function mutations of tumor suppressor genes, like, TP53 , SMAD4 , and CDKN2A

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One mechanism attributed to these outcomes is believed to be the stimulation of β-cell L-type calcium channels, thereby increasing insulin secretions [66]