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Introduction Diabetes mellitus, affecting 29.1 million people in the United States ( Oxidative stress, which occurs when there is an imbalance between generation and removal of reactive oxygen species (ROS), may contribute to β-cell damage during either T1D or T2D ( Types of ROS and Relevance to β-Cell Damage A critical feature of the β-cell is its ability to link changes in metabolic flux, brought on by glucose metabolism, to changes in membrane excitability and subsequent alterations in intracellular Ca 2+ concentration ([Ca 2+ ] i ) and insulin secretion ( 2 on supply of the sugar substrate ( Here, we will focus on three types of ROS: superoxide (O 2 •- ), hydrogen peroxide (H 2 O 2 ), and peroxynitrite (ONOO - )