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Wild-type enzyme and K105X mutants tended to have infinite true k cat and K m values for extrapolated infinite substrate concentrations, suggesting that the enzymes are neither saturated by GSSCys nor GSH (Supplementary Fig

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Unlike mdx mice, which exhibit strong muscle regeneration 9 , partly due to a large pool of active satellite cells and adequate compensation by utrophin, the limited regenerative potential of DMD mdx rats more accurately reflects the chronic and progressive nature of the disease in humans